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| Id: | 8302
| | Autor: | Valentová, K; Sersen, F; Ulrichová, J
| | Título: | Radical scavenging and anti-lipoperoxidative activities of Smallanthus sonchifolius leaf extracts^ien
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| | Fuente: | Washington; American Chemical Society; 2005. 5577-5582 p. ^btab, ^bgraf.
| | Resumen: | Radical scavenging and anti-lipoperoxidative effects of two organic fractions and two aqueous extracts from the leaves of a neglected Andean crop-yacon (Smallanthus sonchifolius Poepp. & Endl., Asteraceae) were determined using various in vitro models. The extracts' total phenolic content was 10.7-24.6 percent. They exhibited DPPH (IC50 16.14-33.39 microg/mL) and HO scavenging activities (4.49-6.51 mg/mL). The extracts did not scavenge phenylglyoxylic ketyl radicals, but they retarded their formation. In the xanthine/xanthine oxidase superoxide radical generating system, the extracts' activities were 26.10-37.67 superoxide dismutase equivalents/mg. As one of the extracts displayed xanthine oxidase inhibitory activity, the effect of the extracts on a nonenzymatically generated superoxide was determined (IC50 7.36-21.01 microg/mL). The extracts inhibited t-butyl hydroperoxide-induced lipoperoxidation of microsomal and mitochondrial membranes (IC50 22.15-465.3 microg/mL). These results make yacon leaves a good candidate for use as a food supplement in the prevention of chronic diseases involving oxidative stress. (AU)^ien.
| | Descriptores: | Plantas Medicinales
Compuestos Fenólicos
Antioxidantes
Peroxidación de Lípido
| | Límites: | Humanos
| | Localización: | PE14.1 |
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